摘要 :
The Jagged/Notch signaling pathways control cell fate determination anddifferentiation, and their dysfunction is associated with humanpathologies involving cardiovascular abnormalities. To determine thepresence of these genes d...
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The Jagged/Notch signaling pathways control cell fate determination anddifferentiation, and their dysfunction is associated with humanpathologies involving cardiovascular abnormalities. To determine thepresence of these genes during vascular response to injury, weanalyzed expression of Jagged1, Jagged2, and Notch1 through 4after balloon catheter denudation of the rat carotid artery.Although low levels of Jagged1, Jagged2, and constitutive expressionof Notch1 were seen in uninjured endothelium, expression ofall was significantly increased in injured vascular cells. HighJagged1 expression was restricted to the regenerating endothelialwound edge, whereas Notch transcripts were abundant in endothelialand smooth muscle cells. To understand the basis for Jagged/Notchcontrol of cellular phenotype, we studied an in vitro modelof NIH3T3 cells transfected with a secreted form of the extracellulardomain of Jagged1. We report that the soluble Jagged1 proteincaused decreased cell-matrix adhesion and cell migration defects.Cadherin-mediated intercellular junctions as well as focal adhesionswere modified in soluble Jagged1 transfectants, demonstratingthat cell-cell contacts and adhesion plaques may be targetsof Jagged/Notch activity. We suggest that Jagged regulationof cell-cell and cell-matrix interactions may contribute tothe control of cell migration in situations of tissue remodelingin vivo.收起
摘要 :
The purpose of the Directory of Illustration, reviewed here in its electronic version but also available in print, is to advertise illustrators and provide them with portfolios. The illustrator has three alternatives when purchasi...
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The purpose of the Directory of Illustration, reviewed here in its electronic version but also available in print, is to advertise illustrators and provide them with portfolios. The illustrator has three alternatives when purchasing annual packets. The price depends on the reservation date, the amount of spread pages, and the amount of online images the artist chooses to purchase. The purchased record will list an advertisement of between 20 ($2,695 annually) to 100 ($4,080 annually) online images; the artist's portfolio with contact information; a short biography and background; blog feed; and an external hyperlink to their website. The information provided about the artist is brief but enough to enable an art director to locate their website directly and get a sense of their work. If there are any questions about the information users are able to contact the artist directly through the phone, e-mail, blog, or website link in the record.
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